Play-N-Skillz got in touch with a Miami-based man called Juan Vibras, who was working with independent label Rich Music and connected them with Snow. The original version of "Con Calma" only featured vocals by Daddy Yankee, who told the producers that the song "needed surprise factor" because they "had to pay tribute to the main author". A month later in Los Angeles, the duo showed the project to Daddy Yankee, who was about to record another track but decided to change his plans. Play-N-Skillz came out with the concept of "Con Calma" during early 2017 and recorded a drum loop, while songwriter Máximo Mundial helped them with the chorus idea. Previously, Daddy Yankee and Play-N-Skillz worked together on the singles "Not a Crime" (2016) and "Azukita" (2018), while Gaby Music co-wrote Daddy Yankee's Latin Grammy Award-winner song " Dura" (2018) and served as recording engineer on 2017's Latin Grammy Award for Record of the Year " Despacito" by Luis Fonsi featuring Daddy Yankee.
"Con Calma" was written by Daddy Yankee, Snow, and Juan "Gaby Music" Rivera, and was produced by American production duo Play-N-Skillz and co-produced by David "Scott Summers" Macias. The song also became the longest-reigning number-one on the Argentina Hot 100, with 10 weeks. Across Europe, the single peaked at number one in the Czech Republic, Italy, the Netherlands, Slovenia, and Spain, and reached the top five in Belgium, Poland, and Switzerland. In the United States, it has topped the Hot Latin Songs chart for 14 weeks. Commercially, the song topped the charts of 20 countries and reached the top 10 of 10 others. It has been described as an uptempo electronics and dancehall song with lyrics about "a woman who works her feminine charms and dances very well".